The Jorg Stetefeld Research Laboratory, University of Manitoba, Department of Chemistry

Welcome to the Stetefeld Laboratory for Structural Biology and Biophysics

Welcome to the lab of Dr. Jörg Stetefeld. The primary goal of our research is to understand in detail the structure-property relationship of protein-protein interaction networks. We are broadly interested in cell surface receptors and their interactions with various ligand molecules, including netrins and CCN family members.

Our principal goal is to gain molecular insights to therapeutically impact human disease. We view structural and biophysical information here as molecular fingerprint for both basic and applied advances. To reveal the underlying mechanistic aspects of extracellular signaling hub formation, we use a combination of:

X-ray crystallography and cryo-3D Electron microscopy in combination with SEC-SAXS and NMR
Several biophysical techniques (a.o. SEC-MALS-QUELS, AUC, MST, nano-DSF-DLS, BLI and iSCAMS)
Advanced MD simulations and Artificial intelligence programs
In vitro and in vivo functional analysis

In 2014, the Center for Oil and Gas Research and Development (COGRAD) was founded as collaborative effort with the laboratory of Dr. Tomy. In this unique, ISO-certified Center powerful tools for live stock mapping and biodiversity monitoring are developed. In 2019, Dr. Stetefeld initiated the Center for Integrated Structural Biophysics (CISB) with the goal to provide a world-class platform for structure-based drug design projects.

last update January 2024